6-Methoxyquinoline-3-carboxylic acid → HCID 178487903, compound

HRID 1019908Notes

Reaction equation

HRID 1019908 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][C:7]([C:13]([OH:15])=[O:14])=[CH:6]2.CO[C:18]([C@H:20]1[CH2:25][CH2:24][C@H:23]([N:26]([CH2:28][C:29]2[CH:38]=[CH:37][C:32]3[O:33][CH2:34][CH2:35][O:36][C:31]=3[CH:30]=2)[CH3:27])[CH2:22][CH2:21]1)=O>>[O:33]1[C:32]2[CH:37]=[CH:38][C:29]([CH2:28][N:26]([CH3:27])[C@H:23]3[CH2:24][CH2:25][C@H:20]([CH2:18][O:14][C:13]([C:7]4[CH:8]=[N:9][C:10]5[C:5]([CH:6]=4)=[CH:4][C:3]([O:2][CH3:1])=[CH:12][CH:11]=5)=[O:15])[CH2:21][CH2:22]3)=[CH:30][C:31]=2[O:36][CH2:35][CH2:34]1

Participants

3

Reactant 2

HCID 142415026-Methoxyquinoline-3-carboxylic acidHCID 178501214HCID 178501214, compound

Product 1

HCID 178487903HCID 178487903, compound

Procedure

The title compound is prepared as a yellow oil following Scheme 2 and in analogy to Example 28 using 6-methoxy-quinoline-3-carboxylic acid and trans-4-[(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-methyl-amino]-cyclohexanecarboxylic acid methyl ester as starting materials.

Sources & evidence

ORD record
ord-3aa17eddd0b44c27983bac011a44de49
Source dataset
uspto-grants-2014_05
Patent number
US08716280B2

Reaction notes

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