HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Benzodioxane-6-carboxylic Acid → 2,3-Dihydro-benzo[1,4]dioxine-6-carboxylic acid {1-[2-(7-methoxy-quinoxalin-2-ylsulfanyl)-ethyl]-piperidin-4-yl}-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Benzodioxane-6-carboxylic Acid | HCID 2758833 | — |
| Reactant | 1-[2-(7-Methoxy-quinoxalin-2-ylsulfanyl)-ethyl]-piperidin-4-ylamine | HCID 66746530 | — |
| Product | 2,3-Dihydro-benzo[1,4]dioxine-6-carboxylic acid {1-[2-(7-methoxy-quinoxalin-2-ylsulfanyl)-ethyl]-piperidin-4-yl}-amide | HCID 46852695 | — |
Reaction Steps
The title compound is prepared as a yellow solid (61 mg, 56% yield) following Scheme 3 and in analogy to Example 35 using 2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid (39 mg, 0.22 mmol 1.0 eq) and 1-[2-(7-methoxy-quinoxalin-2-ylsulfanyl)-ethyl]-piperidin-4-ylamine (70 mg, 0.22 mmol, 1.0 eq) as starting materials.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08716280B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-1a1cbfc128b24ccb89c757562315d358 |
| Source note | uspto-grants-2014_05 |