1-[2-(7-Methoxy-quinoxalin-2-ylsulfanyl)-ethyl]-piperidin-4-ylamine → HCID 46853011, compound

HRID 1019930Notes

Reaction equation

HRID 1019930 reaction equation
[Cl:1][C:2]1[C:11]([CH:12]=O)=[CH:10][C:5]2[NH:6][CH2:7][CH2:8][S:9][C:4]=2[CH:3]=1.[CH3:14][O:15][C:16]1[CH:25]=[C:24]2[C:19]([N:20]=[CH:21][C:22]([S:26][CH2:27][CH2:28][N:29]3[CH2:34][CH2:33][CH:32]([NH2:35])[CH2:31][CH2:30]3)=[N:23]2)=[CH:18][CH:17]=1>>[Cl:1][C:2]1[C:11]([CH2:12][NH:35][CH:32]2[CH2:31][CH2:30][N:29]([CH2:28][CH2:27][S:26][C:22]3[CH:21]=[N:20][C:19]4[C:24](=[CH:25][C:16]([O:15][CH3:14])=[CH:17][CH:18]=4)[N:23]=3)[CH2:34][CH2:33]2)=[CH:10][C:5]2[NH:6][CH2:7][CH2:8][S:9][C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 667465301-[2-(7-Methoxy-quinoxalin-2-ylsulfanyl)-ethyl]-piperidin-4-ylamineHCID 86662004HCID 86662004, compound

Product 1

HCID 46853011HCID 46853011, compound

Procedure

The title compound is prepared as a yellow waxy solid (23 mg, 34% yield) following Scheme 3 and in analogy to Example 40 using 7-chloro-3,4-dihydro-2H-benzo[1,4]thiazine-6-carbaldehyde (27 mg, 0.12 mmol 1.0 eq) and 1-[2-(7-methoxy-quinoxalin-2-ylsulfanyl)-ethyl]-piperidin-4-ylamine (40 mg, 0.12 mmol, 1.0 eq) as starting materials.

Sources & evidence

ORD record
ord-a3082703160845ec9677732598e4f9db
Source dataset
uspto-grants-2014_05
Patent number
US08716280B2

Reaction notes

Loading…