3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid → HCID 46853329, compound

HRID 1019951Notes

Reaction equation

HRID 1019951 reaction equation
Cl[C:2]1[CH:11]=[N:10][C:9]2[C:4](=[CH:5][C:6]([O:12][CH3:13])=[CH:7][CH:8]=2)[N:3]=1.C(O[C:19](=[O:33])[NH:20][CH:21]1[CH2:26][CH2:25][N:24]([CH2:27][CH:28]([OH:32])[CH2:29][O:30][CH3:31])[CH2:23][CH2:22]1)(C)(C)C.[O:34]=[C:35]1[NH:40][C:39]2[CH:41]=[C:42](C(O)=O)[CH:43]=[CH:44][C:38]=2[S:37][CH2:36]1>>[CH3:31][O:30][CH2:29][CH:28]([O:32][C:2]1[CH:11]=[N:10][C:9]2[C:4](=[CH:5][C:6]([O:12][CH3:13])=[CH:7][CH:8]=2)[N:3]=1)[CH2:27][N:24]1[CH2:23][CH2:22][CH:21]([NH:20][C:19]([C:42]2[CH:43]=[CH:44][C:38]3[S:37][CH2:36][C:35](=[O:34])[NH:40][C:39]=3[CH:41]=2)=[O:33])[CH2:26][CH2:25]1

Participants

4

Reactant 3

HCID 7609933-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acidHCID 126864152-Chloro-7-methoxyquinoxalineHCID 66747181HCID 66747181, compound

Product 1

HCID 46853329HCID 46853329, compound

Procedure

The title compound is prepared as an off-white lyophilizated powder following Scheme 1 and in analogy to Example 1 using 2-chloro-7-methoxy-quinoxaline, [1-(2-hydroxy-3-methoxy-propyl)-piperidin-4-yl]-carbamic acid tert-butyl ester and 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid as starting materials.

Sources & evidence

ORD record
ord-3ea1d4d0b3dd472c8f207810fc2217d2
Source dataset
uspto-grants-2014_05
Patent number
US08716280B2

Reaction notes

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