HRID1019965

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID45076484

tert-Butyl [1-(2-hydroxyethyl)piperidin-4-yl]carbamate

C12H24N2O3

HCID46741340

未命名化合物

HCID59560634

未命名化合物

PRODUCTS

生成物

结构：COc1ccc2nc(C)c(OCCN3CCC(NC(=O)c4cc5c(cc4Cl)SCC(=O)N5)CC3)nc2c1

HCID66747359

未命名化合物

PROCEDURE

实验过程

The title compound is prepared as a light yellow lyophilizated powder following Scheme 1 and in analogy to Example 1 using 3-chloro-6-methoxy-2-methyl-quinoxaline, [1-(2-hydroxy-ethyl)-piperidin-4-yl]-carbamic acid tert-butyl ester and 7-chloro-3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid as starting materials.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-fd9e9ffb6fa04862a137e26e571a8ebb
来源数据集: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08716280B2
来源说明: uspto-grants-2014_05

反应 SMILES

Cl[C:2]1[C:3]([CH3:14])=[N:4][C:5]2[C:10]([N:11]=1)=[CH:9][C:8]([O:12][CH3:13])=[CH:7][CH:6]=2.C(O[C:20](=[O:31])[NH:21][CH:22]1[CH2:27][CH2:26][N:25]([CH2:28][CH2:29][OH:30])[CH2:24][CH2:23]1)(C)(C)C.[Cl:32][C:33]1[C:43](C(O)=O)=[CH:42][C:36]2[NH:37][C:38](=[O:41])[CH2:39][S:40][C:35]=2[CH:34]=1>>[CH3:13][O:12][C:8]1[CH:9]=[C:10]2[C:5]([N:4]=[C:3]([CH3:14])[C:2]([O:30][CH2:29][CH2:28][N:25]3[CH2:24][CH2:23][CH:22]([NH:21][C:20]([C:43]4[C:33]([Cl:32])=[CH:34][C:35]5[S:40][CH2:39][C:38](=[O:41])[NH:37][C:36]=5[CH:42]=4)=[O:31])[CH2:27][CH2:26]3)=[N:11]2)=[CH:6][CH:7]=1