HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(Thiophen-2-yl)-1,2-oxazole-3-carboxylic acid → 5-Thiophen-2-yl-isoxazole-3-carboxylic acid {1-[2-(3-methoxy-quinolin-6-yloxy)-ethyl]-piperidin-4-yl}-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(Thiophen-2-yl)-1,2-oxazole-3-carboxylic acid | HCID 3157098 | — |
| Reactant | [1-(2-Hydroxy-ethyl)-piperidin-4-yl]-carbamic acid tert-butyl ester | HCID 45076484 | — |
| Reactant | 3-Methoxy-quinolin-6-ol | HCID 66746554 | — |
| Product | 5-Thiophen-2-yl-isoxazole-3-carboxylic acid {1-[2-(3-methoxy-quinolin-6-yloxy)-ethyl]-piperidin-4-yl}-amide | HCID 66746873 | — |
Reaction Steps
The title compound is prepared as a brown solid following Scheme 1 and in analogy to Example 2 using 3-methoxy-quinolin-6-ol, [1-(2-hydroxy-ethyl)-piperidin-4-yl]-carbamic acid tert-butyl ester and 5-thiophen-2-yl-isoxazole-3-carboxylic acid as starting materials.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08716280B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-bd767b28c81140db9f0acd7e83c42353 |
| Source note | uspto-grants-2014_05 |