2-Mercaptoethanol → HCID 46853487, compound

HRID 1019989Notes

Reaction equation

HRID 1019989 reaction equation
Cl[C:2]1[CH:11]=[N:10][C:9]2[C:4](=[C:5]([O:14][CH3:15])[C:6]([O:12][CH3:13])=[CH:7][CH:8]=2)[N:3]=1.[SH:16][CH2:17][CH2:18]O.C(O[C:25](=[O:33])[NH:26][CH:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1)(C)(C)C.[O:34]=[C:35]1[NH:40][C:39]2[CH:41]=[C:42](C(O)=O)[CH:43]=[CH:44][C:38]=2[S:37][CH2:36]1>>[CH3:13][O:12][C:6]1[C:5]([O:14][CH3:15])=[C:4]2[C:9]([N:10]=[CH:11][C:2]([S:16][CH2:17][CH2:18][N:30]3[CH2:29][CH2:28][CH:27]([NH:26][C:25]([C:42]4[CH:43]=[CH:44][C:38]5[S:37][CH2:36][C:35](=[O:34])[NH:40][C:39]=5[CH:41]=4)=[O:33])[CH2:32][CH2:31]3)=[N:3]2)=[CH:8][CH:7]=1

Participants

5

Reactant 4

HCID 15672-MercaptoethanolHCID 7238334-(N-Boc-amino)piperidineHCID 7609933-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acidHCID 86662010HCID 86662010, compound

Product 1

HCID 46853487HCID 46853487, compound

Procedure

The title compound is prepared as a light brown solid following Scheme 3 and in analogy to Example 35 using 2-chloro-7,8-dimethoxy-quinoxaline, 2-mercaptoethanol, piperidin-4-yl-carbamic acid tert-butyl ester and 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid as starting materials.

Sources & evidence

ORD record
ord-0b401e52ffe7458aa8b74db4b3807d89
Source dataset
uspto-grants-2014_05
Patent number
US08716280B2

Reaction notes

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