Triethylamine → HCID 49787540, compound

Participants

Reaction Steps

1-[7-amino-5-(2-chloro-phenyl)-3,4-dihydro-1H-isoquinolin-2-yl]-2,2,2-trifluoro-ethanone (71 mgs, 0.2 mmoles) was dissolved in anhydrous dimethylacetamide (1 ml) to which was added cyclohexyl carbonyl chloride (40 ul, 0.3 mmoles) followed by triethylamine (41.6 ul, 0.3 mmoles) and the solution flushed with nitrogen and left stirring overnight. The product was purified by semi-preparative C18 HPLC (9.4 mgs, 10.2% yield, 100% pure, CO-AAW00031).

Provenance & Evidence