4-Chlorobenzenesulfonyl chloride → HCID 49787506, compound

Participants

Reaction Steps

1-[7-amino-5-(2-chloro-phenyl)-3,4-dihydro-1H-isoquinolin-2-yl]-2,2,2-trifluoro-ethanone (80 mgs, 0.2 mmoles) was stirred in dichloromethane (12 mls) and triethylamine (80 ul, 0.58 mmoles) was added, followed by 4-chlorobenzenesulphonyl chloride (75 mgs, 0.36 mmoles). The reaction was flushed with nitrogen and left stirring at room temperature overnight. The reaction was purified by semi-preparative C18 HPLC (47 mgs, 44% yield, 100% pure, CO-AAW00034).

Provenance & Evidence