Potassium Carbonate → HCID 66611930, compound

Participants

Reaction Steps

CO-AAW0001 (100 mgs, 0.24 mmoles) was dissolved in methanol (5 mls) followed by the addition of anhydrous potassium carbonate (50 mgs, 0.36 mmoles). The solution was stirred at room temperature for 2 hours. Silica thin layer chromatography in dichloromethane/methanol (95:5) showed reaction to be complete. The reaction was evaporated and the residue dissolved in ethylacetate (20 mls) and water (10 mls). The aqueous layer was re-extracted with ethylacetate (2×10 mls) and the combined organic phases washed with brine (10 mls), dried of magnesium sulphate, filtered and evaporated to produce a yellow oil (˜80% pure, CO-AAW0003). This was used for the next reaction without further purification.

Provenance & Evidence