反应详情

温度

65 °C

The 2-carboxymethylbenzaldehyde hippuric acid adduct from above (1.0 g, 3.3 mmoles) was dissolved in methanol (20 mls) and solid potassium hydroxide (0.37 g, 6.6 mmoles) was added. The clear solution was heated (65° C.) for 1 hour. The reaction was evaporated and the solid residue partitioned between water (25 mls) and ethyl acetate (25 mls). The aqueous layer was further extracted with ethyl acetate (2×10 mls) and the combined ethyl acetate extracts washed with brine (10 mls) water (10 mls). After drying over magnesium sulphate the solution was evaporated to leave a yellow solid (0.68 g, 99% yield).

1. customThe reaction was evaporated
2. customthe solid residue partitioned between water (25 mls) and ethyl acetate (25 mls)
3. extractionThe aqueous layer was further extracted with ethyl acetate (2×10 mls)
4. washthe combined ethyl acetate extracts washed with brine (10 mls) water (10 mls)
5. dry with materialAfter drying over magnesium sulphate the solution
6. customwas evaporated