HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 67291643, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | N-Methylisopropylamine | HCID 78485 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1-(2-Fluorophenyl)isoquinoline-3-carboxylic acid | HCID 13272392 | — |
| Reactant | HCID 178418300 | HCID 178418300 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | HCID 67291643 | HCID 67291643 | 48% |
Reaction Steps
1-(2-fluorophenyl)isoquinoline-3-carboxylic acid (0.910 mgs, 0.34 mmoles) was dissolved in dimethylacetamide (2 mls) to which was added methyl isopropylamine (0.039 mls, 0.37 mmoles), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDCI, 0.071 g, 0.37 mmoles), hydroxyl benzotriazole (HOBt, 0.046 g, 0.34 mmoles) and N,N-diisopropylethylamine (0.056 mls, 0.34 mmoles). The reaction was stirred at room temperature overnight and after evaporation the product was purified by automated C18 HPLC (52.6 mgs, 48% yield, 100% pure, CO-AAW0005).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08716302B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-a87c7f0409ad4d34a53d88742bc34fdf |
| Source note | uspto-grants-2014_05 |