HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → Benzyl 4-(chlorocarbonyl)piperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1-Carbobenzoxy-4-piperidinecarboxylic Acid | HCID 736489 | — |
| Product | Benzyl 4-(chlorocarbonyl)piperidine-1-carboxylate | HCID 2776270 | — |
Reaction Steps
Piperidine-1,4-dicarboxylic acid monobenzyl ester (VI) (5.0 g, 19 mmol) was suspended in thionyl chloride (10 ml) and stirred at room temperature for one hour. Excess thionyl chloride was distilled out and the obtained crude 4-chlorocarbonyl-piperidine-1-carboxylic acid benzyl ester (VII) was used for the next reaction immediately.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08716296B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-798f23db83c54d67b2b589f92e7148f1 |
| Source note | uspto-grants-2014_05 |