反应详情

4-[6-(2-Ethoxy-phenyl)-pyrimidin-4-ylcarbamoyl]-piperidine-1-carboxylic acid benzyl ester (IX) (1.47 g, 3.19 mmol) was dissolved in methanol (20 ml) and 10% Pd/C (0.81 g) was added under an atmosphere of nitrogen. The reaction was stirred at room temperature under hydrogen balloon pressure for 18 hours. The catalyst was filtered from the reaction mixture through a celite bed and the filtrate was evaporated to dryness to obtain piperidine-4-carboxylic acid [6-(2-ethoxy-phenyl)-pyrimidin-4-yl]-amide (compound #1A) (0.61 g, 58%).

1. filtrationThe catalyst was filtered from the reaction mixture through a celite bed
2. customthe filtrate was evaporated to dryness