HCID 59508997, compound → HCID 59509002, compound

Participants

Reaction Steps

4-[6-(2-Fluoro-6-methoxy-phenyl)-pyrimidin-4-ylcarbamoyl]-piperidine-1-carboxylic acid benzyl ester (XXIII) (0.05 g, 0.1 mmol) was dissolved in methanol (5 ml) and 10% Pd/C (0.03 g) was added under an atmosphere of nitrogen. The mixture was stirred at room temperature under hydrogen balloon pressure for 18 hours. The catalyst was removed from the reaction mixture by filtration through a celite bed and the filtrate was evaporated to dryness. The resulting crude product was triturated with dry diethyl ether (2 ml) and concentrated to yield piperidine-4-carboxylic acid [6-(2-fluoro-6-methoxy-phenyl)-pyrimidin-4-yl]-amide (compound #12A) (0.029 g, 81%) as a white solid.

Provenance & Evidence