Dichloromethane → 1-[6-(2-Methoxy-phenyl)-pyrimidin-4-yl]-3-piperidin-4-yl-urea hydrochloride

HRID 1020074Notes

Reaction equation

HRID 1020074 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]([NH:17][C:18]2[CH:23]=[C:22]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[O:30][CH3:31])[N:21]=[CH:20][N:19]=2)=[O:16])[CH2:10][CH2:9]1)=O)(C)(C)C.[Cl:32]CCl>>[ClH:32].[CH3:31][O:30][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=1[C:22]1[N:21]=[CH:20][N:19]=[C:18]([NH:17][C:15]([NH:14][CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[O:16])[CH:23]=1

Participants

3

Reactant 2

HCID 6344DichloromethaneHCID 595090164-{3-[6-(2-Methoxy-phenyl)-pyrimidin-4-yl]-ureido}-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 671854531-[6-(2-Methoxy-phenyl)-pyrimidin-4-yl]-3-piperidin-4-yl-urea hydrochloride

Procedure

To a solution of 4-{3-[6-(2-methoxy-phenyl)-pyrimidin-4-yl]-ureido}-piperidine-1-carboxylic acid tert-butyl ester (XLIV) (0.250 g, 0.585 mmol) in dry dichloromethane (2 ml) ethereal HCl (2 ml) was added and the mixture was stirred for 2 hours at room temperature. The reaction was monitored by TLC. After completion, the solvent was removed from the reaction mixture to provide 0.20 g of 1-[6-(2-methoxy-phenyl)-pyrimidin-4-yl]-3-piperidin-4-yl-urea hydrochloride (Compound #24A).

Workup

  1. customAfter completion, the solvent was removed from the reaction mixture

Sources & evidence

ORD record
ord-eee9b567971d4b5a9656abe68fe06ca5
Source dataset
uspto-grants-2014_05
Patent number
US08716296B2

Reaction notes

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