反应详情

To a solution of 4-{3-[6-(2-methoxy-phenyl)-pyrimidin-4-yl]-ureido}-piperidine-1-carboxylic acid tert-butyl ester (XLIV) (0.250 g, 0.585 mmol) in dry dichloromethane (2 ml) ethereal HCl (2 ml) was added and the mixture was stirred for 2 hours at room temperature. The reaction was monitored by TLC. After completion, the solvent was removed from the reaction mixture to provide 0.20 g of 1-[6-(2-methoxy-phenyl)-pyrimidin-4-yl]-3-piperidin-4-yl-urea hydrochloride (Compound #24A).

1. customAfter completion, the solvent was removed from the reaction mixture