Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| Reactant | HCID 59563749 | HCID 59563749 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 59563693 | HCID 59563693 | — |
Reaction Steps
To tert-butyl 3-(isoquinolin-6-ylamino)-3-oxo-2-(4-(triisopropyl silyloxy)phenyl)propylcarbamate (E7) in THF at 0° C. was added TBAF, and the solution was stirred for 45 min at 0° C. The compound was poured into EtOAc and washed with NH4Cl(sat), dried (Na2SO4), filtered, and evaporated. Column chromatography 6% MeOH/CH2Cl2 gave pure tert-butyl 2-(4-hydroxyphenyl)-3-(isoquinolin-6-ylamino)-3-oxopropylcarbamate (E8).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08716310B2 |
|---|
| Source dataset | uspto-grants-2014_05 |
|---|
| ORD ID | ord-6dfd43680b594acbba2d03dcfefd8279 |
|---|
| Source note | uspto-grants-2014_05 |
|---|
