Dichloromethane → HCID 66599754, compound

HRID 1020120Notes

Reaction equation

HRID 1020120 reaction equation
[OH:1][CH2:2][C:3]1[S:7][C:6]([CH:8]([C:18]([NH:20][C:21]2[CH:22]=[C:23]3[C:28](=[CH:29][CH:30]=2)[CH:27]=[N:26][CH:25]=[CH:24]3)=[O:19])[CH2:9][NH:10]C(=O)OC(C)(C)C)=[CH:5][CH:4]=1.C(Cl)[Cl:32]>>[ClH:32].[ClH:32].[NH2:10][CH2:9][CH:8]([C:6]1[S:7][C:3]([CH2:2][OH:1])=[CH:4][CH:5]=1)[C:18]([NH:20][C:21]1[CH:22]=[C:23]2[C:28](=[CH:29][CH:30]=1)[CH:27]=[N:26][CH:25]=[CH:24]2)=[O:19]

Participants

3

Reactant 2

HCID 6344DichloromethaneHCID 59563710HCID 59563710, compound

Product 1

HCID 66599754HCID 66599754, compound

Procedure

To a solution of tert-butyl 2-(5-(hydroxymethyl)thiophen-2-yl)-3-(isoquinolin-6-ylamino)-3-oxopropylcarbamate (E238) in CH2Cl2 was added 4 NHCl-dioxane and the solution was stirred for 4 h. The solvents were evaporated to give 3-amino-2-(5-(hydroxymethyl)thiophen-2-yl)-N-(isoquinolin-6-yl)propanamide dihydrochloride (E239).

Workup

  1. customThe solvents were evaporated

Sources & evidence

ORD record
ord-4f89a32fb63145faac8f57e6b329328b
Source dataset
uspto-grants-2014_05
Patent number
US08716310B2

Reaction notes

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