HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1020131Generated: October 30, 2026
Tetrabutylammonium Fluoride → HCID 59563761, compound
https://huagongshe.com/reaction/1020131
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| Reactant | HCID 59563770 | HCID 59563770 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 59563761 | HCID 59563761 | — |
Reaction Steps
To tert-butyl 4-(isoquinolin-6-ylamino)-4-oxo-3-(4-(triisopropylsilyloxy)phenyl)butylcarbamate (E306) in THF at 0° C. was added TBAF and the solution was stirred at 0° C. for 30 min. The solution was poured into NH4Cl(sat) and extracted with EtOAc. The combined organics were dried (Na2SO4), filtered, and evaporated. Column chromatography (SiO2, 5-8% MeOH/CH2Cl2) gave pure tert-butyl 3-(4-hydroxyphenyl)-4-(isoquinolin-6-ylamino)-4-oxobutylcarbamate (E307).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08716310B2 |
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| Source dataset | uspto-grants-2014_05 |
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| ORD ID | ord-8f99dc5135a94009a81aaa3eea6577ff |
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| Source note | uspto-grants-2014_05 |
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