HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1020143Generated: October 30, 2026
Tetrabutylammonium Fluoride → HCID 59563733, compound
https://huagongshe.com/reaction/1020143
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| Reactant | HCID 59563712 | HCID 59563712 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 59563733 | HCID 59563733 | — |
Reaction Steps
To N-(isoquinolin-6-yl)-2-phenyl-3-(triisopropylsilyloxy)propanamide (E401) in THF cooled to 0° C. was added TBAF and this solution was stirred for 3 h at 0° C. The mixture was poured into EtOAc/NH4Cl(sat) and washed with NH4Cl(sat). The organics were dried (Na2SO4), filtered, and evaporated. Column chromatography (0-10% MeOH/CH2Cl2) gave pure 3-hydroxy-N-(isoquinolin-6-yl)-2-phenylpropanamide (E402).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08716310B2 |
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| Source dataset | uspto-grants-2014_05 |
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| ORD ID | ord-63fb23bfa75b4fe493ef722c7c76b591 |
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| Source note | uspto-grants-2014_05 |
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