HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1020144Generated: October 30, 2026
Methanesulfonyl chloride → HCID 59563709, compound
https://huagongshe.com/reaction/1020144
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | HCID 59563733 | HCID 59563733 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 59563709 | HCID 59563709 | — |
Reaction Steps
To 3-hydroxy-N-(isoquinolin-6-yl)-2-phenylpropanamide (E402) in pyridine at 0° C. was added MsCl, and this solution was stirred at 0° C. for 2.5 h. The mixture was poured into NaHCO3(sat) and extracted with EtOAc. The combined organics were dried (Na2SO4), filtered, and evaporated to give 3-(isoquinolin-6-ylamino)-3-oxo-2-phenylpropyl methanesulfonate (E403).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08716310B2 |
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| Source dataset | uspto-grants-2014_05 |
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| ORD ID | ord-1f09827cd3924e3f8cd8fd9e046e9a05 |
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| Source note | uspto-grants-2014_05 |
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