2,2-dimethyltetrahydro-2H-pyran-4-amine → HCID 52917266, compound

HRID 1020160Notes

Reaction equation

HRID 1020160 reaction equation
CS([C:5]1[N:10]=[CH:9][C:8]([C:11]#[C:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:7][N:6]=1)(=O)=O.[CH3:19][C:20]1([CH3:27])[CH2:25][CH:24]([NH2:26])[CH2:23][CH2:22][O:21]1>>[CH3:19][C:20]1([CH3:27])[CH2:25][CH:24]([NH:26][C:5]2[N:10]=[CH:9][C:8]([C:11]#[C:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[CH:7][N:6]=2)[CH2:23][CH2:22][O:21]1

Participants

3

Reactant 2

HCID 38092032,2-dimethyltetrahydro-2H-pyran-4-amineHCID 575167582-Methanesulfonyl-5-phenylethynyl-pyrimidine

Product 1

HCID 52917266HCID 52917266, compound

Procedure

The title compound, MS: m/e=308.2 (M+H+), can be prepared in accordance with the general method of example 1, step 3 from 2-methanesulfonyl-5-phenylethynyl-pyrimidine (example 1, step 2) and rac-2,2-dimethyl-tetrahydro-pyran-4-ylamine.

Sources & evidence

ORD record
ord-ee2ca3ebec3e480394afa52271ec544a
Source dataset
uspto-grants-2014_05
Patent number
US08716316B2

Reaction notes

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