7-Oxa-bicyclo[2.2.1]hept-2-ylamine → HCID 57517063, compound

HRID 1020161Notes

Reaction equation

HRID 1020161 reaction equation
CS([C:5]1[N:10]=[CH:9][C:8]([C:11]#[C:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:7][N:6]=1)(=O)=O.[CH:19]12[O:25][CH:22]([CH2:23][CH2:24]1)[CH2:21][CH:20]2[NH2:26]>>[CH:19]12[O:25][CH:22]([CH2:23][CH2:24]1)[CH2:21][CH:20]2[NH:26][C:5]1[N:10]=[CH:9][C:8]([C:11]#[C:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:7][N:6]=1

Participants

3

Reactant 2

HCID 122646267-Oxa-bicyclo[2.2.1]hept-2-ylamineHCID 575167582-Methanesulfonyl-5-phenylethynyl-pyrimidine

Product 1

HCID 57517063HCID 57517063, compound

Procedure

The title compound, MS: m/e=292.1 (M+H+), can be prepared in accordance with the general method of example 1, step 3 from 2-methanesulfonyl-5-phenylethynyl-pyrimidine (example 1, step 2) and rac-(7-oxa-bicyclo[2.2.1]hept-2-yl)amine (can be prepared in accordance with the literature described in the patent EP 1958666).

Sources & evidence

ORD record
ord-18ac6f1f0784459a89af2f3ecf990ffa
Source dataset
uspto-grants-2014_05
Patent number
US08716316B2

Reaction notes

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