2-Methanesulfonyl-5-phenylethynyl-pyrimidine → HCID 178501205, compound

HRID 1020162Notes

Reaction equation

HRID 1020162 reaction equation
CS([C:5]1[N:10]=[CH:9][C:8]([C:11]#[C:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:7][N:6]=1)(=O)=O.Cl.[CH3:20][O:21][C:22]([C@H:24]1[CH2:29][CH2:28][C@H:27]([NH2:30])[CH2:26][CH2:25]1)=[O:23]>>[CH3:20][O:21][C:22]([C@H:24]1[CH2:29][CH2:28][C@H:27]([NH:30][C:5]2[N:10]=[CH:9][C:8]([C:11]#[C:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[CH:7][N:6]=2)[CH2:26][CH2:25]1)=[O:23]

Participants

3

Reactant 2

HCID 575167582-Methanesulfonyl-5-phenylethynyl-pyrimidineHCID 178501210HCID 178501210, compound

Product 1

HCID 178501205HCID 178501205, compound

Procedure

The title compound, MS: m/e=336.4 (M+H+), can be prepared in accordance with the general method of example 1, step 3 from 2-methanesulfonyl-5-phenylethynyl-pyrimidine (example 1, step 2) and trans-4-amino-cyclohexylcarboxylic acid methyl ester hydrochloride.

Sources & evidence

ORD record
ord-2bfe1d3a0a454f60b8cc90245be59761
Source dataset
uspto-grants-2014_05
Patent number
US08716316B2

Reaction notes

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