Phenylacetylene → HCID 178521602, compound

HRID 1020172Notes

Reaction equation

HRID 1020172 reaction equation
[F:1][C:2]1[C:3]([NH:9][C@H:10]2[CH2:15][CH2:14][C@H:13]([OH:16])[CH2:12][CH2:11]2)=[N:4][CH:5]=[C:6](I)[CH:7]=1.[C:17]1([C:23]#[CH:24])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[F:1][C:2]1[C:3]([NH:9][C@H:10]2[CH2:15][CH2:14][C@H:13]([OH:16])[CH2:12][CH2:11]2)=[N:4][CH:5]=[C:6]([C:24]#[C:23][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 10821PhenylacetyleneHCID 178521606HCID 178521606, compound

Product 1

HCID 178521602HCID 178521602, compound

Procedure

The title compound, yellow solid, MS: m/e=311.2 (M+H+), can be prepared in accordance with the general method of example 1, step 1 from trans-4-(3-fluoro-5-iodopyridin-2-ylamino)cyclohexanol (example 18, step 1) and phenylacetylene.

Sources & evidence

ORD record
ord-d791d1953a7e4e34a4cdf6991daab169
Source dataset
uspto-grants-2014_05
Patent number
US08716316B2

Reaction notes

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