4-Aminomethyltetrahydropyran → HCID 57517073, compound

HRID 1020174Notes

Reaction equation

HRID 1020174 reaction equation
CS([C:5]1[N:10]=[CH:9][C:8]([C:11]#[C:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:7][N:6]=1)(=O)=O.[O:19]1[CH2:24][CH2:23][CH:22]([CH2:25][NH2:26])[CH2:21][CH2:20]1>>[C:13]1([C:12]#[C:11][C:8]2[CH:7]=[N:6][C:5]([NH:26][CH2:25][CH:22]3[CH2:23][CH2:24][O:19][CH2:20][CH2:21]3)=[N:10][CH:9]=2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 27732104-AminomethyltetrahydropyranHCID 575167582-Methanesulfonyl-5-phenylethynyl-pyrimidine

Product 1

HCID 57517073HCID 57517073, compound

Procedure

The title compound, white solid, MS: m/e=294.2 (M+H+), can be prepared in accordance with the general method of example 1, step 3 from 2-methanesulfonyl-5-phenylethynyl-pyrimidine (example 1, step 2) and (tetrahydro-2H-pyran-4-yl)methanamine.

Sources & evidence

ORD record
ord-bcc479f49bbe418982c63a3d26213b1c
Source dataset
uspto-grants-2014_05
Patent number
US08716316B2

Reaction notes

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