1,4-Cyclohexanediol → HCID 52917036, compound

HRID 1020176Notes

Reaction equation

HRID 1020176 reaction equation
CS([C:5]1[N:10]=[CH:9][C:8]([C:11]#[C:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:7][N:6]=1)(=O)=O.[CH:19]1([OH:26])[CH2:24][CH2:23][CH:22]([OH:25])[CH2:21][CH2:20]1>>[C:13]1([C:12]#[C:11][C:8]2[CH:7]=[N:6][C:5]([O:25][CH:22]3[CH2:23][CH2:24][CH:19]([OH:26])[CH2:20][CH2:21]3)=[N:10][CH:9]=2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 111621,4-CyclohexanediolHCID 575167582-Methanesulfonyl-5-phenylethynyl-pyrimidine

Product 1

HCID 52917036HCID 52917036, compound

Procedure

The title compound, yellow solid, MS: m/e=295.3 (M+H+), can be prepared in accordance with the general method of example 1, step 3 from 2-methanesulfonyl-5-phenylethynyl-pyrimidine (example 1, step 2) and cyclohexane-1,4-diol by using Cs2CO3 as base and dioxane as solvent for 16 hours at 100° C.

Sources & evidence

ORD record
ord-8101cb3dbff946fe9cceeb217d0bfec8
Source dataset
uspto-grants-2014_05
Patent number
US08716316B2

Reaction notes

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