Phenylacetylene → HCID 57517074, compound

HRID 1020180Notes

Reaction equation

HRID 1020180 reaction equation
F[C:2]1[C:7]([F:8])=[CH:6][C:5](I)=[CH:4][N:3]=1.[CH:10]1([OH:17])[CH2:15][CH2:14][CH:13]([OH:16])[CH2:12][CH2:11]1.[C:18]1([C:24]#[CH:25])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[F:8][C:7]1[C:2]([O:16][CH:13]2[CH2:14][CH2:15][CH:10]([OH:17])[CH2:11][CH2:12]2)=[N:3][CH:4]=[C:5]([C:25]#[C:24][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:6]=1

Participants

4

Reactant 3

HCID 10821PhenylacetyleneHCID 111621,4-CyclohexanediolHCID 113224272,3-Difluoro-5-iodopyridine

Product 1

HCID 57517074HCID 57517074, compound

Procedure

The title compound, yellow oil, MS: m/e=312.1 (M+H+), can be prepared in accordance with the general method of example 18 from 2,3-difluoro-5-iodopyridine, cyclohexane-1,4-diol and phenylacetylene.

Sources & evidence

ORD record
ord-6c5d3bdefe6847cc9d42c54e4c159fb6
Source dataset
uspto-grants-2014_05
Patent number
US08716316B2

Reaction notes

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