3-Methylpyrrolidin-2-one → rac-3-Methyl-1-(5-phenylethynyl-pyridin-2-ylmethyl)-pyrrolidin-2-one

HRID 1020193Notes

Reaction equation

HRID 1020193 reaction equation
[C:1]1([C:7]#[C:8][C:9]2[CH:10]=[CH:11][C:12]([CH2:15]O)=[N:13][CH:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:17][CH:18]1[CH2:22][CH2:21][NH:20][C:19]1=[O:23]>>[CH3:17][CH:18]1[CH2:22][CH2:21][N:20]([CH2:15][C:12]2[CH:11]=[CH:10][C:9]([C:8]#[C:7][C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)=[CH:14][N:13]=2)[C:19]1=[O:23]

Participants

3

Reactant 2

HCID 1028483-Methylpyrrolidin-2-oneHCID 57517077(5-Phenylethynyl-pyridin-2-yl)-methanol

Product 1

HCID 52917267rac-3-Methyl-1-(5-phenylethynyl-pyridin-2-ylmethyl)-pyrrolidin-2-one

Procedure

The title compound, light yellow oil, MS: m/e=291.1 (M+H+), can be prepared in accordance with the general method of example 31, step 2 from (5-phenylethynyl-pyridin-2-yl)-methanol (example 31, step 1) and rac-3-methyl-pyrrolidin-2-one.

Sources & evidence

ORD record
ord-f5e31f3ae07846a8b92eb267eb2f2ef7
Source dataset
uspto-grants-2014_05
Patent number
US08716316B2

Reaction notes

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