2-Oxazolidinone → rac-3-[1-(5-Phenylethynyl-pyridin-2-yl)-ethyl]-oxazolidin-2-one

HRID 1020196Notes

Reaction equation

[C:1]1([C:7]#[C:8][C:9]2[CH:10]=[CH:11][C:12]([CH:15](O)[CH3:16])=[N:13][CH:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[O:18]1[CH2:22][CH2:21][NH:20][C:19]1=[O:23]>>[C:1]1([C:7]#[C:8][C:9]2[CH:10]=[CH:11][C:12]([CH:15]([N:20]3[CH2:21][CH2:22][O:18][C:19]3=[O:23])[CH3:16])=[N:13][CH:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

Reactant 2

HCID 739492-Oxazolidinone

HCID 57517078rac-1-(5-Phenylethynyl-pyridin-2-yl)-ethanol

Product 1

HCID 52917114rac-3-[1-(5-Phenylethynyl-pyridin-2-yl)-ethyl]-oxazolidin-2-one

Procedure

The title compound, white solid, MS: m/e=293.1 (M+H+), can be prepared in accordance with the general method of example 31, step 2 from rac-1-(5-phenylethynyl-pyridin-2-yl)-ethanol (example 42, step 1) and oxazolidin-2-one.

Sources & evidence

ORD record: ord-ad8bb17798e14b88bb70e2d0ad2a695b
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08716316B2

Reaction notes

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