Water → HCID 178513363, compound

Participants

Reaction Steps

150 mg 5-[5-(4-Trifluoromethyl-phenyl)-2,3-dihydro-indole-1-sulfonyl]-thiophene-2-carbonitrile were dissolved in a mixture of 8 ml tetrahydrofuran and 8 ml methanol. 600 mg hydroxylamine hydrochloride were added followed by the addition of 1.20 ml triethylamine. The reaction mixture was stirred at room temperature for four hours. The mixture was poured on 100 ml water and extracted five times with portions of 50 ml ethylacetate. The combined organic extracts were washed with 100 ml brine, dried over MgSO4 and the solvent was evaporated in vacuo to obtain 163 mg N-Hydroxy-5-[5-(4-trifluoromethyl-phenyl)-2,3-dihydro-indole-1-sulfonyl]-thiophene-2-carboxamidine. This material was used without further purification.

Provenance & Evidence