Hydrochloric Acid → HCID 86622752, compound

Participants

Reaction Steps

A solution of tert-butyl 2-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methoxy)-ethylcarbamate (Example 77) (350 mg) in 1,4-dioxane (3 mL) was treated with 4N HCl in 1,4-dioxane (4 mL). The mixture was stirred overnight, 5 mL of diethyl ether was added, and the precipitated material was isolated by filtration. 1H-NMR (300 MHz, DMSO-d6): 10.85 (bs, 1H), 7.90 (bs, 2H), 7.60 (d, 1H), 7.50 (s, 1H), 7.27 (d, 1H), 6.97 (s, 1H), 4.43 (s, 2H), 4.30 (d, 2H), 3.60 (m, 2H), 2.98 (m, 2H).

Provenance & Evidence