Trifluoroacetic acid → HCID 86622757, compound

Participants

Reaction Steps

({2-[3-(3,4-Dichloro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amino)-acetic acid tert-butyl ester (Example 109) was treated with trifluoroacetic acid overnight. The TFA was removed by evaporation the residue was triturated with 2N HCl in diethyl ether to afford the title compound. 1H-NMR (300 MHz, CD3OD): δ 7.48 (d, 2H), 7.25 (d, 2H), 7.18 (s, 1H), 4.40 (s, 2H), 4.33 (s, 2H), 3.89 (s, 2H), 2.91 (s, 3H). M/z (pos. ESI)=402 (M+H).

Provenance & Evidence