2,4-Dimethoxybenzylamine → HCID 25052214, compound

Participants

Reaction Steps

1-(3,4-dichlorobenzyl)-3-(4-(iodomethyl)thiazol-2-yl)urea (Intermediate XXII) was taken up in THF and an excess of the 2,4-dimethoxy-benzylamine (20 equiv.) was added. The reaction was allowed to stir overnight at room temperature. The volatiles were removed in vacuo. Resulting oil triturated with water to give a gooey solid. Water was decanted off and resulting residue was purified by column chromatography (DCM, 0-8% MeOH saturated with NH3). 1H NMR (400 MHz, CDCl3): 7.32 (d, 1H), 7.19 (br s, 1H), 7.01 (br d, 1H), 6.96 (d, 1H), 6.60 (s, 1H), 6.40-6.33 (m, 2H), 4.11 (br s, 2H), 3.78 (s, 3H), 3.71 (s, 3H), 3.69 (br s, 2H), 3.55 (br s, 3H).

Provenance & Evidence