Sodium Hydroxide → 2-(3-(3,4-Dichlorobenzyl)ureido)thiazole-4-carboxylic acid

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Reaction Steps

Sodium hydroxide (24 mL, 24 mmol, 1N in water) was added to an ethanol (50 mL) solution of ethyl 2-(3-(3,4-dichlorobenzyl)ureido)thiazole-4-carboxylate (Example 38) (1.8 g, 4.8 mmol). The mixture was stirred overnight. The ethanol was removed by evaporation and the aqueous solution was filtered then the filter was washed with water (20 ml). The pH of the filtrate was adjusted to less than three with concentrated HCl. The precipitate was filtered, washed with water and dried to afford 2-(3-(3,4-dichlorobenzyl)ureido)thiazole-4-carboxylic acid.

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