Methylamine → N,3-Dimethylpyrazin-2-amine

Participants

Reaction Steps

2-chloro-3-methylpyrazine (124 mg, 1.0 mmol) and methylamine (5 mL, 2M solution in THF) was irradiated in a microwave oven at 190° C. for 10 hours. The solution is evaporated and the residue was dissolved in CH2Cl2 (10 mL). It was partitioned with NaOH (1 mL, 5N), dried with NaSO4, filtered and volatiles removed in vacuo to afford N,3-dimethylpyrazin-2-amine. 1H NMR (400 MHz, CDCl3): 7.92 (d, 1H), 7.70 (d, 1H), 4.40 (s, br, 1H), 3.03 (d, 3H), 2.36 (s, 3H). MS (ES+): M/Z 124 (M+1).

Provenance & Evidence