HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 3-(Chloromethyl)-N-[(2,4-dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 5-Chloro-3-(chloromethyl)-1,2,4-thiadiazole | HCID 332610 | — |
| Reactant | 2,4-Dimethoxybenzylamine | HCID 597250 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(Chloromethyl)-N-[(2,4-dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine | HCID 58055088 | — |
Reaction Steps
5-Chloro-3-chloromethyl-[1,2,4]thiadiazole (10 mmol) is added to a solution of 2,4-dimethoxybenzylamine (10 mmol) in THF at room temperature followed by addition of DIEA (10 mmol). The mixture is stirred overnight. The white precipitate is filtered and washed with THF. The filtrate is concentrated to oil and dried under high vacuum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08716320B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-933dc3d9cef64b1abaa1534c83b7617a |
| Source note | uspto-grants-2014_05 |