Hydrochloric Acid → HCID 57461785, compound

Participants

Reaction Steps

LiOH.H2O (0.096 g, 2.28 mmol) was added to a solution of ethyl 2-(2-oxopyrrolidin-1-yl)-4-(trifluoromethyl)oxazole-5-carboxylate (A-30) (0.140 g, 0.48 mmol) in THF/CH3OH/H2O (2/2/0.5 mL) at RT followed by stirring overnight. The reaction mixture was diluted with EtOAc/H2O (25/25 mL) and neutralized with 2.5 mL of 1 M HCl. The organic phase was separated, dried over MgSO4, filtered, and concentrated. The residue was dried in vacuo to yield 2-(2-oxopyrrolidin-1-yl)-4-(trifluoromethyl)oxazole-5-carboxylic acid (A-31) as a white solid (0.120 g, 95% yield). 1H NMR (500 MHz, CD3OD) δ 5.18 (br s, 1H), 3.41 (t, 2H, J=6.8 Hz), 2.42 (t, 2H, J=7.2 Hz), 1.93 (m, 2H).

Provenance & Evidence