HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Aminoindole → N-(1H-indol-5-yl)-2-(3-methyl-1-piperidinyl)-4-(trifluoromethyl)-5-oxazolecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Aminoindole | HCID 78867 | — |
| Reactant | N-[6-(4-hydroxy-4-phenylpiperidin-1-yl)pyridin-3-yl]-2-(piperidin-1-yl)-4-(trifluoromethyl)oxazole-5-carboxamide | HCID 46208786 | — |
| Product | N-(1H-indol-5-yl)-2-(3-methyl-1-piperidinyl)-4-(trifluoromethyl)-5-oxazolecarboxamide | HCID 67391262 | — |
Reaction Steps
Compound 44 was prepared by the general procedure for compound 1, by using intermediates A-10 and 5-aminoindole as starting materials. 1H NMR (500 MHz, DMSO-d6) δ 11.10 (br s, 1H), 10.01 (s, 1H), 7.36 (m, 2H), 7.30 (br d, 1H, J=6.8 Hz), 6.41 (s, 1H), 4.12 (m, 2H), 3.29 (br s, 1H), 3.05 (t, 1H, J=12.3 Hz), 2.74 (t, 1H, J=12.2 Hz), 1.70 (m, 3H), 1.53 (m, 1H), 1.15 (m, 1H), 0.94 (d, 3H, J=6.0 Hz). MS (M+1): 393.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08716312B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-d54f602691874a5c9ce953313281eb91 |
| Source note | uspto-grants-2014_05 |