HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Nitrophenyl isocyanate → 5-[[2-(3-methyl-1-piperidinyl)-4-(trifluoromethyl)-5-oxazoly]carbonylamino]-N-(2-nitrophenyl)-1H-indole-1-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Nitrophenyl isocyanate | HCID 76834 | — |
| Reactant | N-(2,6-dichlorophenyl)-5-[[2-(3-methyl-1-piperidinyl)-4-(trifluoromethyl)-5-oxazolyl]carbonylamino]-1H-indole-1-carboxamide | HCID 67391139 | — |
| Reactant | N-(1H-indol-5-yl)-2-(3-methyl-1-piperidinyl)-4-(trifluoromethyl)-5-oxazolecarboxamide | HCID 67391262 | — |
| Product | 5-[[2-(3-methyl-1-piperidinyl)-4-(trifluoromethyl)-5-oxazoly]carbonylamino]-N-(2-nitrophenyl)-1H-indole-1-carboxamide | HCID 57485443 | — |
Reaction Steps
Compound 47 was prepared by the general procedure for compound 45, using compound 44 and 2-nitrophenyl isocyanate as starting materials. 1H NMR (500 MHz, DMSO-d6) δ 10.55 (br s, 1H), 10.18 (br s, 1H), 8.14 (br d, 1H, J=8.5 Hz), 8.08 (br s, 1H), 8.05 (br d, 1H, J=8.5 Hz), 8.00 (br d, 1H, J=8.0 Hz), 7.79 (tm, 1H, J=7.6 Hz), 7.72 (br d, 1H, J=8.2 Hz), 7.51 (br d, 1H, J=8.2 Hz), 7.46 (m, 1H), 6.84 (m, 1H), 4.13 (m, 2H), 3.06 (br t, 1H, J=12.0 Hz), 2.76 (br t, 1H, J=11.7 Hz), 1.74 (m, 3H), 1.54 (m, 1H), 1.16 (m, 1H), 0.94 (d, 3H, J=6.3 Hz). MS (M+1): 557.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08716312B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-6bcf524b9ea3403494d56c882d3f4397 |
| Source note | uspto-grants-2014_05 |