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HRID1020371

反应详情

EQUATION

反应方程式

HRID 1020371 的结构方程式

REACTANTS

反应物

3
结构：O=C(CBr)Oc1ccccc1
HCID564919

Phenyl bromoacetate

C8H7BrO2

结构：CC1CCCN(c2nc(C(F)(F)F)c(C(=O)Nc3ccc4c(ccn4C(=O)Nc4c(Cl)cccc4Cl)c3)o2)C1
HCID67391139

未命名化合物

结构：CC1CCCN(c2nc(C(F)(F)F)c(C(=O)Nc3ccc4[nH]ccc4c3)o2)C1
HCID67391262

未命名化合物

PRODUCTS

生成物

1
结构：CC1CCCN(c2nc(C(F)(F)F)c(C(=O)Nc3ccc4c(ccn4CC(=O)Oc4ccccc4)c3)o2)C1
HCID67391617

未命名化合物

PROCEDURE

实验过程

Compound 48 was prepared by the general procedure for compound 45, by using compound 44 and phenyl 2-bromoacetate as starting materials. 1H NMR (500 MHz, DMSO-d6) δ 10.22 (br s, 1H), 8.29 (m, 1H), 8.08 (m, 1H), 7.96 (dd, 1H, J=3.5, 13.3 Hz), 7.58 (m, 1H), 7.45 (m, 1H), 7.34 (m, 2H), 7.07 (d, 1H, J=8.5 Hz), 6.99 (t, 1H, J=7.4 Hz), 6.85 (m, 1H), 4.84 (s, 2H), 4.15 (d, 1H, J=13.2 Hz), 4.10 (d, 1H, J=13.6 Hz), 3.06 (t, 1H, J=12.0 Hz), 2.76 (dd, 1H, J=11.0, 12.3 Hz), 1.71 (m, 3H), 1.54 (m, 1H), 1.15 (m, 1H); 0.94 (d, 3H, J=6.3 Hz). MS (M+1): 527.