HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-pyrrolo(2,3-b)pyridin-5-amine → N-[1H-pyrrolo[2,3-b]pyridin-5-yl]-2-(3-methyl-1-piperidinyl)-4-(trifluoromethyl)-5-oxazolecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-pyrrolo(2,3-b)pyridin-5-amine | HCID 11715187 | — |
| Reactant | N-[6-(4-hydroxy-4-phenylpiperidin-1-yl)pyridin-3-yl]-2-(piperidin-1-yl)-4-(trifluoromethyl)oxazole-5-carboxamide | HCID 46208786 | — |
| Product | N-[1H-pyrrolo[2,3-b]pyridin-5-yl]-2-(3-methyl-1-piperidinyl)-4-(trifluoromethyl)-5-oxazolecarboxamide | HCID 67390591 | — |
Reaction Steps
Compound 54 was prepared by the general procedure for compound 1, by using compound A-10 and 5-amino-7-azaindole as starting materials. 1H NMR (500 MHz, DMSO-d6) δ 11.67 (s, 1H), 10.21 (s, 1H), 8.37 (s, 1H), 8.23 (s, 1H), 7.50 (s, 1H), 6.46 (m, 1H), 4.13 (m, 2H), 3.07 (m, 1H), 2.75 (t, 1H, J=11.7 Hz), 1.77 (m, 2H), 1.67 (m, 1H), 1.54 (m, 1H), 1.15 (m, 1H), 0.94 (d, 3H, J=6.3 Hz). MS (M+1): 394.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08716312B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-31ba2becf0c64efa97cd706d64f7b19e |
| Source note | uspto-grants-2014_05 |