HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Amino-2-N-Boc-1,2,3,4-tetrahydro-isoquinoline → HCID 68238559, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Amino-2-N-Boc-1,2,3,4-tetrahydro-isoquinoline | HCID 2756371 | — |
| Reactant | N-[6-(4-hydroxy-4-phenylpiperidin-1-yl)pyridin-3-yl]-2-(piperidin-1-yl)-4-(trifluoromethyl)oxazole-5-carboxamide | HCID 46208786 | — |
| Product | HCID 68238559 | HCID 68238559 | — |
Reaction Steps
Compound 153 was prepared by the general procedure for compound 1, by using compound A-4 and tert-butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate as the starting materials. 1H NMR (400 MHz, DMSO-d6) δ 10.06 (s, 1H), 7.54 (s, 1H), 7.47 (d, 1H, J=8.4 Hz), 7.15 (d, 1H, J=8.4 Hz), 4.47 (s, 2H), 3.61 (m, 4H), 3.55 (t, 2H, J=5.9 Hz), 2.77 (t, 2H, J=5.9 Hz), 1.61 (m, 6H), 1.43 (s, 9H); LCMS (ESI) Rt=5.47 min, [M+1]+ 495.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08716312B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-6cbe238bf2ff4a538ad41b5b713c1d50 |
| Source note | uspto-grants-2014_05 |