Lithium hydroxide, monohydrate → HCID 66688686, compound

Participants

Reaction Steps

Methyl 4-((4-bromo-5,6-dimethoxy-1-oxoisoindolin-2-yl)methyl)benzoate (500 mg, 1.19 mmol) in the step 2 and lithium hydroxide monohydrate (199 mg, 4.76 mmol, 4 equiv.) were dissolved in a mixture of THF and distilled water (mixture ratio=2:1 (v/v), 10 mL), and stirred at room temperature for 1 night. The reaction proceeded until no starting material is detectable by TLC. The resulting mixture thus obtained was distilled under a reduced pressure to remove THF. The resulting material was dissolved in distilled water and 1N HCl was added thereto to be pH 2. White precipitates thus obtained were filtered and dried under vacuum to obtain the title compound (380 mg, 78%).

Provenance & Evidence