Trifluoroacetic acid → HCID 49804807, compound

Participants

Reaction Steps

The procedure of the Step 1 in Example 39 was repeated except that tert-butyl 2-(4-((5,6-dimethoxy-1-oxo-4-(pyridin-3-yl)isoindolin-2-yl)methyl)benzamido)-4-(thiophen-2-yl)phenylcarbamate in the Step 2 of Example 48 instead of N-(benzyloxy)-6-(BOC-amino)hexanamide and a mixture of CH2Cl2 and trifluoroacetic acid (mixture ratio=1:1 (v/v)) were used, and the reaction was performed for 3 hrs, to obtain the title compound (99%).

Provenance & Evidence