3-Pyridinylboronic acid → HCID 49805670, compound

HRID 1020434Notes

Reaction equation

HRID 1020434 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][NH:16][C:17](=[O:26])[C:18]1[CH:23]=[CH:22][C:21](Br)=[C:20]([CH3:25])[CH:19]=1)=[O:10].[N:27]1[CH:32]=[CH:31][CH:30]=[C:29](B(O)O)[CH:28]=1>>[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][NH:16][C:17](=[O:26])[C:18]1[CH:23]=[CH:22][C:21]([C:29]2[CH:28]=[N:27][CH:32]=[CH:31][CH:30]=2)=[C:20]([CH3:25])[CH:19]=1)=[O:10]

Participants

3

Reactant 2

HCID 27343783-Pyridinylboronic acidHCID 49805562HCID 49805562, compound

Product 1

HCID 49805670HCID 49805670, compoundYield 63%

Procedure

The procedure of Example 81 was repeated except for using N-(5-(2-aminophenylcarbamoyl)pentyl)-4-bromo-3-methylbenzamide instead of N-(5-(2-aminophenylcarbomoyl)pentyl)-3-bromo-2-methylbenzamide, and 3-pyridinyl boronic acid instead of phenyl boronic acid to obtain the title compound (32 mg, 63%).

Sources & evidence

ORD record
ord-82c8e3df91a44c7986af70f7bb9f8982
Source dataset
uspto-grants-2014_05
Patent number
US08716326B2

Reaction notes

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