(Pyridin-4-yl)boronic acid → HCID 49805671, compound

HRID 1020435Notes

Reaction equation

HRID 1020435 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][NH:16][C:17](=[O:26])[C:18]1[CH:23]=[CH:22][C:21](Br)=[C:20]([CH3:25])[CH:19]=1)=[O:10].[N:27]1[CH:32]=[CH:31][C:30](B(O)O)=[CH:29][CH:28]=1>>[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][NH:16][C:17](=[O:26])[C:18]1[CH:23]=[CH:22][C:21]([C:30]2[CH:31]=[CH:32][N:27]=[CH:28][CH:29]=2)=[C:20]([CH3:25])[CH:19]=1)=[O:10]

Participants

3

Reactant 2

HCID 2734379(Pyridin-4-yl)boronic acidHCID 49805562HCID 49805562, compound

Product 1

HCID 49805671HCID 49805671, compoundYield 63%

Procedure

The procedure of Example 81 was repeated except for using N-(5-(2-aminophenylcarbamoyl)pentyl)-4-bromo-3-methylbenzamide instead of N-(5-(2-aminophenylcarbomoyl)pentyl)-3-bromo-2-methylbenzamide, and 4-pyridinyl boronic acid instead of phenyl boronic acid to obtain the title compound (32 mg, 63%).

Sources & evidence

ORD record
ord-27feaa280691488f8d30185fcc32df6f
Source dataset
uspto-grants-2014_05
Patent number
US08716326B2

Reaction notes

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