3,5-Dimethylphenylboronic acid → HCID 49805673, compound

HRID 1020436Notes

Reaction equation

HRID 1020436 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][NH:16][C:17](=[O:26])[C:18]1[CH:23]=[CH:22][C:21](Br)=[C:20]([CH3:25])[CH:19]=1)=[O:10].[CH3:27][C:28]1[CH:29]=[C:30](B(O)O)[CH:31]=[C:32]([CH3:34])[CH:33]=1>>[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][NH:16][C:17](=[O:26])[C:18]1[CH:23]=[CH:22][C:21]([C:30]2[CH:31]=[C:32]([CH3:34])[CH:33]=[C:28]([CH3:27])[CH:29]=2)=[C:20]([CH3:25])[CH:19]=1)=[O:10]

Participants

3

Reactant 2

HCID 27343493,5-Dimethylphenylboronic acidHCID 49805562HCID 49805562, compound

Product 1

HCID 49805673HCID 49805673, compoundYield 77%

Procedure

The procedure of Example 81 was repeated except for using N-(5-(2-aminophenylcarbamoyl)pentyl)-4-bromo-3-methylbenzamide instead of N-(5-(2-aminophenylcarbomoyl)pentyl)-3-bromo-2-methylbenzamide, and 3,5-dimethyl phenyl boronic acid instead of phenyl boronic acid to obtain the title compound (35 mg, 77%).

Sources & evidence

ORD record
ord-1a223d34aabb4cc1b23570cb2754660a
Source dataset
uspto-grants-2014_05
Patent number
US08716326B2

Reaction notes

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