Hexamethylphosphoramide → HCID 13544732, compound

Participants

Reaction Conditions

Reaction Steps

50 gms, 0.208 moles of 4-amino-2-chloro-6,7-dimethoxyquinazoline and 21.2 gms, 0.252 moles of 3-methylaminopropionitrile were charged in a round bottom flask containing 350 ml hexamethylphosphoramide. The reaction mass was stirred at about 100° C. for 9 hours, cooled to a temperature of 25° C. and then charged with 250 ml isopropanol. The reaction mass was further stirred for 15 minutes, filtered and washed with 50 ml isopropanol and subjected to drying at 50° C. for 7-8 hours to yield N-(4-amino-6,7-dimethoxyquinazol-2-yl)-N-methyl-2-cyanoethylamine hydrochloride (43 gms).

Provenance & Evidence