Ammonia → HCID 53446128, compound

HRID 1020716Notes

Reaction equation

HRID 1020716 reaction equation
[ClH:1].[NH2:2][C:3]1[C:12]2[C:7](=[CH:8][C:9]([O:15][CH3:16])=[C:10]([O:13][CH3:14])[CH:11]=2)[N:6]=[C:5]([N:17]([CH2:19][CH2:20][C:21]#N)[CH3:18])[N:4]=1.[NH3:23]>[Ni].C(O)C>[ClH:1].[NH2:2][C:3]1[C:12]2[C:7](=[CH:8][C:9]([O:15][CH3:16])=[C:10]([O:13][CH3:14])[CH:11]=2)[N:6]=[C:5]([N:17]([CH3:18])[CH2:19][CH:20]([NH2:23])[CH3:21])[N:4]=1

Participants

5

Reactant 2

HCID 222AmmoniaHCID 13544732HCID 13544732, compound

Product 1

HCID 53446128HCID 53446128, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

50 gms, 0.154 moles of N-(4-amino-6,7-dimethoxyquinazol-2-yl)-N-methyl-2-cyanoethylamine hydrochloride, 50 gms Raney-Nickel, 600 ml aqueous ammonia solution and 400 ml denatured spirit (denatured ethanol) were charged in an autoclave.

Workup

  1. additionwere charged in an autoclave

Sources & evidence

ORD record
ord-399208e9672b435fbc81541d6a38cbed
Source dataset
uspto-grants-2014_05
Patent number
US08716476B2

Reaction notes

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